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A 15-year-old boy with Wiskott-Aldrich syndrome.His neurologic illness was heralded by dysarthria and right-sided weakness and the diagnosis was established by brain biopsy specimen.Survival from the time of onset of MPL was 10 months.Although PML typically occurs in the setting of severe acquired cellular immunodeficiency,often as a consequence of acquired immunodeficiency syndrome,organ transplantation,and leukemia and lymphoma, it may rarely accompany inherited immunodeficiency syndromes.The reported childhood cases of PML include three patients,aged 5,11 and 18 years,with other inherited immunodeficiency syndromes.This patient represents the first time(to our knowledge)that PML has been reported to occur in association with Wiskott-Aldrich syndrome. |
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